Quantifying Motor Impairments

Healthcare, clinical trials, and research related to neurological disease all require tools for accurately and objectively measuring motor impairments. Our first tool, called Hevelius, measures motor impairment in the dominant arm based on a person's performance on a simple computer mouse-based task. We are working on other tools as well as on ways to make accurate measurements possible at home without help from clinician. Such at-home measurements can enable granular longitudinal measurements of disease progresson as well as large-scale assessments. This project is done in collaboration with the Laboratory for Deep Neurophenotyping at Massachusetts General Hospital.

Nergis C Khan, Vineet Pandey, Krzysztof Z Gajos, and Anoopum S Gupta. Free-Living Motor Activity Monitoring in Ataxia-Telangiectasia. The Cerebellum, pages 1-12, 2021.
[Abstract, BibTeX, etc.]

Krzysztof Z. Gajos, Katharina Reinecke, Mary Donovan, Christopher D. Stephen, Albert Y. Hung, Jeremy D. Schmahmann, and Anoopum S. Gupta. Computer Mouse Use Captures Ataxia and Parkinsonism, Enabling Accurate Measurement and Detection. Movement Disorders, 35:354–358, February 2020.
[Abstract, BibTeX, etc.]